Jul 6, 2020 · Bubonic plague, the disease's most common form, refers to telltale buboes—painfully swollen lymph nodes—that appear around the groin, armpit, or neck. The skin sores become black, leading to ... Find 86 ways to say PLAGUE, along with antonyms, related words, and example sentences at Thesaurus.com, the world's most trusted free thesaurus.Plague Inc. is a unique mix of high strategy and terrifyingly realistic simulation. Your pathogen has just infected 'Patient Zero'. Now you must bring about the end of human history by evolving a deadly, global Plague whilst adapting against everything humanity can do to defend itself. Brilliantly executed with innovative gameplay and built ...Before covid-19, this was the world’s most recent pandemic, infecting as much as 21 percent of the world’s population. Swine flu was a hodgepodge of several different flu strains that had ...PLAGUE. Plague is a disease of rodents and their fleas that can be transmitted to humans. Throughout history, plague, often referred to as the " Black Death ," has caused catastrophic pandemics resulting in deaths of tens of millions of persons. The disease is caused by a gram-negative bacterium, Yersinia pestis.plague of [sth] n. figurative ( [sth] bad and persistent) serie, ondata nf. Anna has suffered a plague of misfortunes. Anna è stata vittima di una serie di disgrazie. plague [sb/sth] ⇒ vtr. figurative, often passive (afflict) (figurato) flagellare ⇒ vtr. That country has been plagued by misfortune. Nov 22, 2021 · The Moscow Plague. The Moscow plague hit the earth in 1770. It mainly impacted the Moscow people. And, it was believed to be a replication of the bubonic plague. The plague killed an average of 50 ... History of Plague Epidemics. The plague has afflicted humanity for thousands of years.1, 2, 3 Molecular studies identified the presence of the Y. pestis plague DNA genome in 2 Bronze Age skeletons dated at roughly 3800 years old. 9 In the biblical book 1 Samuel from approximately 1000 BCE, the Philistines experience an outbreak of tumors associated with rodents, which might have been bubonic ...Experts believe that the name “Black Plague” was a mistranslation of the Latin word “atra mors” which could mean either “terrible” or “black.”. It was originally estimated that on average, a third of the population of affected areas was wiped out by the plague over its most destructive decade between 1346 and 1353, but other ...plague of [sth] n. figurative ( [sth] bad and persistent) serie, ondata nf. Anna has suffered a plague of misfortunes. Anna è stata vittima di una serie di disgrazie. plague [sb/sth] ⇒ vtr. figurative, often passive (afflict) (figurato) flagellare ⇒ vtr. That country has been plagued by misfortune. The Justinian Plague of 541-544 . The first great pandemic of bubonic plague where people were recorded as suffering from the characteristic buboes and septicaemia was the Justinian Plague of 541 CE, named after Justinian I, the Roman emperor of the Byzantine Empire at the time. The epidemic originated in Ethiopia in Africa and spread to ...Plague Inc. is a unique mix of high strategy and terrifyingly realistic simulation with over 700 million games played! Your pathogen has just infected 'Patient Zero'. Now you must bring about the end of human history by evolving a deadly, global Plague whilst adapting against everything humanity can do to defend itself.The Plague Disease and Plague as a Bioweapon sections of this Safety and Health Topic provide extensive information on the hazards associated with plague and applicable controls. Additional guidance specific to various types of workers, and associated issues on recognizing and controlling exposure to plague is provided in the following sections ... Plague is an illness you get from Yersinia pestis bacterium. You usually get the most common form (bubonic plague) from flea bites, but you can get pneumonic plague from someone who’s infected. Plague caused deadly pandemics in the past and still exists in many countries today. You can survive plague if you’re treated with antibiotics quickly. FIG 1. Transmission, diagnosis, treatment, and prevention of plague. Plague is a zoonotic disease caused by Yersinia pestis, whose natural life cycle includes rodents and fleas. Plague can be transmitted to humans through the bite of an infected flea, close contact with animals suffering from plague, or respiratory droplets of an infected ...Collection. by Mark Cartwright. published on 26 March 2020. Plagues have swept through humanity ever since communities have gathered together in concentrated groups. In this collection of resources, we look at just some of the pandemics that raged throughout Antiquity and the Middle Ages, from the plague that ripped through Athens in the 5th ...Plague. Plague, caused by the bacterium Yersinia pestis, is a disease that affects humans and other mammals. People typically get infected after being bitten by a rodent flea that is carrying the bacterium or by handling a plague-infected animal. Although the disease killed millions in Europe during the Middle Ages, antibiotics effectively ...Apr 20, 2023 · Plague symptoms are sudden and serious. If you are coughing or sneezing, you should wear a mask. You will likely go to an emergency room. If plague is suspected, you'll see a specialist in infectious disease. What you can do. If you are helping a person with plague-like symptoms, you can prepare for the appointment by taking the following steps: Evidence suggests Washtenaw County’s criminal legal system is rife with disparities based on race, and those are among the 65 recommendations of a sprawling new report released on Aug. 31 that ...Aug 29, 2023 · The Latin word also is the source of Old Irish plag (genitive plaige) "plague, pestilence," German Plage, Dutch plaage. Meaning "epidemic that causes many deaths" is from 1540s; specifically in reference to bubonic plague from c. 1600. Modern spelling follows French, which had plague from 15c. Weakened sense of "anything annoying" is from c. 1600. 11 hours ago · Since the Act was enacted in 1966, NHTSA has recalled more than 390 million cars, trucks, buses, recreational vehicles, motorcycles, and mopeds. From 2018 through 2022 there were about 32 million ... History of Plague Epidemics. The plague has afflicted humanity for thousands of years.1, 2, 3 Molecular studies identified the presence of the Y. pestis plague DNA genome in 2 Bronze Age skeletons dated at roughly 3800 years old. 9 In the biblical book 1 Samuel from approximately 1000 BCE, the Philistines experience an outbreak of tumors associated with rodents, which might have been bubonic ...Bubonic plague is one of three types of plague caused by the bacterium Yersinia pestis. [1] One to seven days after exposure to the bacteria, flu-like symptoms develop. [1] These symptoms include fever, headaches, and vomiting, [1] as well as swollen and painful lymph nodes occurring in the area closest to where the bacteria entered the skin. [2] “[Blurbs] are a PLAGUE on this industry” said Lucy Carson (emphasis her own), a literary agent at The Friedrich Agency who has worked with literary bigwigs like Pulitzer Prize-winner Elizabeth ...plague meaning: 1. to cause worry, pain, or difficulty to someone or something over a period of time: 2. to annoy…. Learn more.Bubonic plague, the disease's most common form, refers to telltale buboes—painfully swollen lymph nodes—that appear around the groin, armpit, or neck. The skin sores become black, leading to ...Here’s how five of the world’s worst pandemics finally ended. 1. Plague of Justinian—No One Left to Die. Yersinia pestis, formerly pasteurella pestis, was the bacteria responsible for the ...Plague is an illness you get from Yersinia pestis bacterium. You usually get the most common form (bubonic plague) from flea bites, but you can get pneumonic plague from someone who’s infected. Plague caused deadly pandemics in the past and still exists in many countries today. You can survive plague if you’re treated with antibiotics quickly.Explore the history of the European plague doctor, and find out where their iconic outfit of a beaked mask and robe came from.--The year is 1656. Your body i...The plague bacteria can be transmitted to humans in the following ways: Flea bites. Plague bacteria are most often transmitted by the bite of an infected flea. During plague epizootics, many rodents die, causing hungry fleas to seek other sources of blood. People and animals that visit places where rodents have recently died from plague are at ...Pneumonic plague is the most serious form of the disease and the only form that can spread from person to person. As a result of a bioterrorist attack, sick people would likely be seen outside the areas where plague naturally occurs due to the potential for release in other areas and person-to-person spread between close contacts. a. : an epidemic disease causing a high rate of mortality : pestilence. b. : a virulent contagious febrile disease that is caused by a bacterium (Yersinia pestis) and that occurs in bubonic, pneumonic, and septicemic forms. called also black death. 3. a.Plague Inc. is a unique mix of high strategy and terrifyingly realistic simulation with over 700 million games played! Your pathogen has just infected 'Patient Zero'. Now you must bring about the end of human history by evolving a deadly, global Plague whilst adapting against everything humanity can do to defend itself. Brilliantly executed ... Plague is a febrile illness that typically manifests into one or more clinical syndromes, often reflecting the route of exposure to the bacterium. These clinical syndromes include bubonic, septicemic, and pneumonic plague. Several classes of antibiotics are effective against plague. Plague can be rapidly fatal if appropriate antimicrobial ... 3. The Italian Plague of 1629-31. Even after the Black Death ended, the bubonic plague continued to sporadically rear its ugly head in Europe for several centuries. One of the most calamitous ...May 18, 2023 · Plague. Plague, caused by the bacterium Yersinia pestis, is a disease that affects humans and other mammals. People typically get infected after being bitten by a rodent flea that is carrying the bacterium or by handling a plague-infected animal. Although the disease killed millions in Europe during the Middle Ages, antibiotics effectively ... Nov 22, 2021 · The Moscow Plague. The Moscow plague hit the earth in 1770. It mainly impacted the Moscow people. And, it was believed to be a replication of the bubonic plague. The plague killed an average of 50 ... Nov 27, 2018 · New plague vaccines are in development but are not expected to be commercially available in the immediate future. Page last reviewed: November 27, 2018 Content source: Centers for Disease Control and Prevention , National Center for Emerging and Zoonotic Infectious Diseases (NCEZID) , Division of Vector-Borne Diseases (DVBD) Plague is an illness you get from Yersinia pestis bacterium. You usually get the most common form (bubonic plague) from flea bites, but you can get pneumonic plague from someone who’s infected. Plague caused deadly pandemics in the past and still exists in many countries today. You can survive plague if you’re treated with antibiotics quickly. plague of [sth] n. figurative ( [sth] bad and persistent) ~의 재앙 명. Anna has suffered a plague of misfortunes. 안나는 불운의 재앙을 겪었다. plague [sb/sth] ⇒ vtr. figurative, often passive (afflict) ~에 피해를 주다, ~을 괴롭히다. That country has been plagued by misfortune. Aug 6, 2021 · Plague is a disease that affects humans and other mammals. It is caused by the bacterium, Yersinia pestis. Humans usually get plague after being bitten by a rodent flea that is carrying the plague bacterium or by handling an animal infected with plague. Plague is infamous for killing millions of people in Europe during the Middle Ages. Feb 28, 2022 · The plague is a serious bacterial infection that can be deadly. Sometimes referred to as the “black plague,” the disease is caused by a bacterial strain called Yersinia pestis.This bacterium ... plague meaning: 1. to cause worry, pain, or difficulty to someone or something over a period of time: 2. to annoy…. Learn more.Define plague. plague synonyms, plague pronunciation, plague translation, English dictionary definition of plague. ) n. 1. a. A highly infectious epidemic disease ... Treatment for plague begins as soon as the health care provider suspects the disease. Treatment is typically done in the hospital. Antibiotics that may be used include the following: Gentamicin. Doxycycline (Monodox, Vibramycin, others). Ciprofloxacin (Cipro). Levofloxacin. Moxifloxacin (Avelox). Chloramphenicol.Mar 12, 2020 · In the 17th century, people believed these outfits could purify poisonous air. They were wrong. During the 17th-century European plague, physicians wore beaked masks, leather gloves, and long ... Septicemic plague (Black Death or black plague) symptoms and signs include fever, weakness, abdominal pain, chills, and shock. Tissue bleeding and death may cause the dying tissues to appear black. Pneumonic plague symptoms and signs include characteristic pneumonia symptoms like chest pain, shortness of breath, cough, fever, chills, nausea ...The bubonic plague - named the Black Death by later historians - was caused by the yersinia pestis bacteria, which lived in rodent populations and was spread by fleas that had bitten infected animals. Once the plague transferred to animals that were in close contact with humans and to humans themselves, it began to spread along established ... Plague is caused by Yersinia pestis bacteria. It can be a life-threatening infection if not treated promptly. Plague has caused several major epidemics in Europe and Asia over the last 2,000 years. Plague has most famously been called "the Black Death" because it can cause skin sores that form black scabs. A plague epidemic in the 14th century ...Plague is a disease that affects humans and other mammals. It is caused by the bacterium, Yersinia pestis. Humans usually get plague after being bitten by a rodent flea that is carrying the plague bacterium or by handling an animal infected with plague. Plague is infamous for killing millions of people in Europe during the Middle Ages.The Justinian Plague of 541-544 . The first great pandemic of bubonic plague where people were recorded as suffering from the characteristic buboes and septicaemia was the Justinian Plague of 541 CE, named after Justinian I, the Roman emperor of the Byzantine Empire at the time. The epidemic originated in Ethiopia in Africa and spread to ...The Crossword Solver found 60 answers to "plague", 4 letters crossword clue. The Crossword Solver finds answers to classic crosswords and cryptic crossword puzzles. Enter the length or pattern for better results. Click the answer to find similar crossword clues . Enter a Crossword Clue.Plague. Plague is an infectious disease of animals and humans caused by a bacterium named Yersinia pestis. People usually get plague from the bite of a rodent flea that is carrying plague bacteria or by handling an infected animal. Although plague is a rare disease, about half of US cases each year occur in New Mexico. Antibiotics are effective ... Plague. Plague is an infectious disease of animals and humans caused by a bacterium named Yersinia pestis. People usually get plague from the bite of a rodent flea that is carrying plague bacteria or by handling an infected animal. Although plague is a rare disease, about half of US cases each year occur in New Mexico. Antibiotics are effective ... Mar 28, 2023 · Septicemic plague (Black Death or black plague) symptoms and signs include fever, weakness, abdominal pain, chills, and shock. Tissue bleeding and death may cause the dying tissues to appear black. Pneumonic plague symptoms and signs include characteristic pneumonia symptoms like chest pain, shortness of breath, cough, fever, chills, nausea ... Apr 20, 2023 · Plague symptoms are sudden and serious. If you are coughing or sneezing, you should wear a mask. You will likely go to an emergency room. If plague is suspected, you'll see a specialist in infectious disease. What you can do. If you are helping a person with plague-like symptoms, you can prepare for the appointment by taking the following steps: Apr 16, 2020 · The Black Death of 1347-1352 CE is the most infamous plague outbreak of the medieval world, unprecedented and unequaled until the 1918-1919 CE flu pandemic in the modern age. The cause of the plague was unknown and, in accordance with the general understanding of the Middle Ages, was attributed to supernatural forces and, primarily, the will or ... Methods. CDC developed these guidelines after reviewing existing data on treatment and prophylaxis of plague, collecting and summarizing additional evidence, and gathering input from approximately 90 experts in numerous fields, including infectious diseases, emergency medicine, pharmacology, neonatology, obstetrics and gynecology, geriatrics, microbiology, epidemiology, and crisis standards of ...Plague Inc. is a unique mix of high strategy and terrifyingly realistic simulation. Your pathogen has just infected 'Patient Zero'. Now you must bring about the end of human history by evolving a deadly, global Plague whilst adapting against everything humanity can do to defend itself. Brilliantly executed with innovative gameplay and built ...plague definition: 1. to cause worry, pain, or difficulty to someone or something over a period of time: 2. to annoy…. Learn more. Jun 15, 2023 · The disease is most common in parts of Africa, Asia and South America, but it also occurs in some areas of the western United States. Symptoms can include an abrupt onset of chills, fever, and enlarged, painful lymph nodes (buboes). Most cases of plague resolve with effective treatment, though treatment must be started immediately to avoid life ... plague meaning: 1. to cause worry, pain, or difficulty to someone or something over a period of time: 2. to annoy…. Learn more. Plague Inc. is a unique mix of high strategy and terrifyingly realistic simulation with over 700 million games played! Your pathogen has just infected 'Patient Zero'. Now you must bring about the end of human history by evolving a deadly, global Plague whilst adapting against everything humanity can do to defend itself. Brilliantly executed ... Plague is transmitted between animals and humans by the bite of infected fleas, direct contact with infected tissues, and inhalation of infected respiratory droplets. Plague can be a very severe disease in people, with a case-fatality ratio of 30% to 60% for the bubonic type, and is always fatal for the pneumonic kind when left untreated.3. The Italian Plague of 1629-31. Even after the Black Death ended, the bubonic plague continued to sporadically rear its ugly head in Europe for several centuries. One of the most calamitous ...The 10-year-old child who died of plague earlier this month was a La Plata County resident. Plague is caused by bacteria and usually is transmitted by bites from infected fleas. Prairie dogs ...The Plague Disease and Plague as a Bioweapon sections of this Safety and Health Topic provide extensive information on the hazards associated with plague and applicable controls. Additional guidance specific to various types of workers, and associated issues on recognizing and controlling exposure to plague is provided in the following sections ... Mar 26, 2020 · Collection. by Mark Cartwright. published on 26 March 2020. Plagues have swept through humanity ever since communities have gathered together in concentrated groups. In this collection of resources, we look at just some of the pandemics that raged throughout Antiquity and the Middle Ages, from the plague that ripped through Athens in the 5th ... Pneumonic plague is the most serious form of the disease and the only form that can spread from person to person. As a result of a bioterrorist attack, sick people would likely be seen outside the areas where plague naturally occurs due to the potential for release in other areas and person-to-person spread between close contacts. Pneumonic plague transmission Although plague can sometimes spread from person to person, this is rare.1 A person who has pneumonia caused by plague may cough up droplets that contain plague bacteria. These bacteria-containing droplets can cause pneumonic plague if they are breathed in by another person nearby.Bubonic plague: Humans can come into contact with plague when an infected flea bites a person or when materials that have plague bacteria enter through a break (a cut or sore) in a person's skin. This is the most common form of plague. Pneumonic plague: Humans can come into contact with plague when a person breathes in plague bacteria from the air.The plague of Justinian or Justinianic plague (541–549 AD) was a bubonic plague epidemic and the first recorded major outbreak of the first plague pandemic: the first Old World pandemic of plague, the contagious disease caused by the bacterium Yersinia pestis. The disease afflicted the entire Mediterranean Basin, Europe, and the Near East ...Feb 28, 2022 · The plague is a serious bacterial infection that can be deadly. Sometimes referred to as the “black plague,” the disease is caused by a bacterial strain called Yersinia pestis.This bacterium ... Oct 12, 2016 · The plague laid siege to the city of London several times during the 16th and 17th centuries, most famously between 1665 and 1666. The pestilence first arose in the suburb of St. Giles-in-the ... plague: [noun] a disastrous evil or affliction : calamity. a destructively numerous influx or multiplication of a noxious animal : infestation. Bubonic plague can advance and spread to the lungs, which is the more severe type of plague called Pneumonic plague. Pneumonic plague – or lung-based plague – is the most virulent form of plague. Incubation can be as short as 24 hours. Any person with pneumonic plague may transmit the disease via droplets to other humans.The bubonic plague - named the Black Death by later historians - was caused by the yersinia pestis bacteria, which lived in rodent populations and was spread by fleas that had bitten infected animals. Once the plague transferred to animals that were in close contact with humans and to humans themselves, it began to spread along established ... There are three kinds of Plague disease: Bubonic plague disease – It is an infection in the lymph nodes of the body. The lymph nodes swell and cause serious pain and it is transmitted through the fleas that contain the bacteria. Pneumonic plague disease – It is a contagious disease that causes infection in the lungs.Black Death, pandemic that ravaged Europe between 1347 and 1351, taking a proportionately greater toll of life than any other known epidemic or war up to that time. The Black Death is widely thought to have been the result of plague, caused by infection with the bacterium Yersinia pestis.Plague is a febrile illness that typically manifests into one or more clinical syndromes, often reflecting the route of exposure to the bacterium. These clinical syndromes include bubonic, septicemic, and pneumonic plague. Several classes of antibiotics are effective against plague. Plague can be rapidly fatal if appropriate antimicrobial ...Oct 29, 2020 · Plague is a serious infectious disease that affects mammals, including humans. It can spread through animal or human contact. The bacteria that cause plague live in many parts of the world ... Oct 29, 2020 · Plague is a serious infectious disease that affects mammals, including humans. It can spread through animal or human contact. The bacteria that cause plague live in many parts of the world ... How to pronounce plague. How to say plague. Listen to the audio pronunciation in the Cambridge English Dictionary. Learn more. Sep 24, 2020 · History of Plague Epidemics. The plague has afflicted humanity for thousands of years.1, 2, 3 Molecular studies identified the presence of the Y. pestis plague DNA genome in 2 Bronze Age skeletons dated at roughly 3800 years old. 9 In the biblical book 1 Samuel from approximately 1000 BCE, the Philistines experience an outbreak of tumors associated with rodents, which might have been bubonic ... Plague definition, an epidemic disease that causes high mortality; pestilence. See more. Plague. Plague is an infectious disease of animals and humans caused by a bacterium named Yersinia pestis. People usually get plague from the bite of a rodent flea that is carrying plague bacteria or by handling an infected animal. Although plague is a rare disease, about half of US cases each year occur in New Mexico. Antibiotics are effective ... Before covid-19, this was the world’s most recent pandemic, infecting as much as 21 percent of the world’s population. Swine flu was a hodgepodge of several different flu strains that had ...Define plague. plague synonyms, plague pronunciation, plague translation, English dictionary definition of plague. ) n. 1. a. A highly infectious epidemic disease ...
Bubonic plague, the disease's most common form, refers to telltale buboes—painfully swollen lymph nodes—that appear around the groin, armpit, or neck. The skin sores become black, leading to .... Vxnr
The Black Death was a bubonic plague pandemic, which reached England in June 1348. It was the first and most severe manifestation of the second pandemic, caused by Yersinia pestis bacteria. The term Black Death was not used until the late 17th century. Originating in Asia, it spread west along the trade routes across Europe and arrived on the ...Jul 22, 2021 · The 10-year-old child who died of plague earlier this month was a La Plata County resident. Plague is caused by bacteria and usually is transmitted by bites from infected fleas. Prairie dogs ... The 10-year-old child who died of plague earlier this month was a La Plata County resident. Plague is caused by bacteria and usually is transmitted by bites from infected fleas. Prairie dogs ...Mar 12, 2020 · In the 17th century, people believed these outfits could purify poisonous air. They were wrong. During the 17th-century European plague, physicians wore beaked masks, leather gloves, and long ... “[Blurbs] are a PLAGUE on this industry” said Lucy Carson (emphasis her own), a literary agent at The Friedrich Agency who has worked with literary bigwigs like Pulitzer Prize-winner Elizabeth ..."Plague is a must-read book so revolutionary in its implications that its author courageously faced character assassination and unlawful incarceration to keep her findings from being relegated to the dustbin of medical history. Riveting, if not at times paradigm shifting, this book reveals a dark side to modern mediThe plague hits Marseille, Paris and Normandy, and then the strain splits, with one strain moving onto the now-Belgian city of Tournai to the east and the other passing through Calais. and Avignon ...FIG 1. Transmission, diagnosis, treatment, and prevention of plague. Plague is a zoonotic disease caused by Yersinia pestis, whose natural life cycle includes rodents and fleas. Plague can be transmitted to humans through the bite of an infected flea, close contact with animals suffering from plague, or respiratory droplets of an infected ...Plague was present in at least one location in the Islamic world virtually every year between 1500 and 1850. [56] Plague repeatedly struck the cities of North Africa. Algiers lost 30,000–50,000 to it in 1620–1621, and again in 1654–1657, 1665, 1691, and 1740–1742. [57] plague meaning: 1. to cause worry, pain, or difficulty to someone or something over a period of time: 2. to annoy…. Learn more. The plague is a serious bacterial infection that can be deadly. Sometimes referred to as the “black plague,” the disease is caused by a bacterial strain called Yersinia pestis.This bacterium ...3. The Italian Plague of 1629-31. Even after the Black Death ended, the bubonic plague continued to sporadically rear its ugly head in Europe for several centuries. One of the most calamitous ...The Black Death was a bubonic plague pandemic, which reached England in June 1348. It was the first and most severe manifestation of the second pandemic, caused by Yersinia pestis bacteria. The term Black Death was not used until the late 17th century. Originating in Asia, it spread west along the trade routes across Europe and arrived on the ... Play Plague Inc. Online in Browser. Plague Inc. is a simulation game developed by Miniclip.com and now.gg allows playing game online in your browser. There are many more interesting online games that you can explore here. READ MORE FAQs.Mar 26, 2020 · Collection. by Mark Cartwright. published on 26 March 2020. Plagues have swept through humanity ever since communities have gathered together in concentrated groups. In this collection of resources, we look at just some of the pandemics that raged throughout Antiquity and the Middle Ages, from the plague that ripped through Athens in the 5th ... Septicemic plague (Black Death or black plague) symptoms and signs include fever, weakness, abdominal pain, chills, and shock. Tissue bleeding and death may cause the dying tissues to appear black. Pneumonic plague symptoms and signs include characteristic pneumonia symptoms like chest pain, shortness of breath, cough, fever, chills, nausea ...The Latin word also is the source of Old Irish plag (genitive plaige) "plague, pestilence," German Plage, Dutch plaage. Meaning "epidemic that causes many deaths" is from 1540s; specifically in reference to bubonic plague from c. 1600. Modern spelling follows French, which had plague from 15c. Weakened sense of "anything annoying" is from c. 1600.New plague vaccines are in development but are not expected to be commercially available in the immediate future. Page last reviewed: November 27, 2018 Content source: Centers for Disease Control and Prevention , National Center for Emerging and Zoonotic Infectious Diseases (NCEZID) , Division of Vector-Borne Diseases (DVBD)plague翻译：不斷困擾;折磨;使受煎熬, （尤指因不停提問而）使煩惱，打攪, 瘟疫。了解更多。3. The Italian Plague of 1629-31. Even after the Black Death ended, the bubonic plague continued to sporadically rear its ugly head in Europe for several centuries. One of the most calamitous ....